Non-Aqueous Acid-Base Titrations in Pharmaceutical Analysis

Non aqueous titrations pdf

A fully automatic system for acid-base coulometric titrations

An automatic system for acid-base titrations by electrogeneration of H(+) and OH(-) ions, with potentiometric end-point detection, was developed. The system includes a PC-compatible computer for instrumental control, data acquisition and processing, which allows up to 13 samples to be analysed sequentially with no human intervention.The system performance was tested on the titration of standard...

A Dipstick Sensor for Coulometric Acid-base Titrations

By performing an acid-base titration by coulometric generation of OHor H+ ions at an inert electrode in close proximity to the pH-sensitive gate of an ISFET, it is possible to determine the acid or base concentration of a solution using the ISFET as an indicator device for the equivalence point in the titration curve. Typical values for the titration time are 0.1 to 10 s for acid or base concen...

Non-aqueous Titration of Gatifloxacin in Pharmaceutical Formulations using Perchloric Acid

An inexpensive, simple, precise and rapid method for the determination of fluoroquinolone gatifloxacin in tablets is described. The procedure is based on the use of volumetric dosage in a non-aqueous medium in glacial acetic acid with 0.1 M perchloric acid. The method validation yielded good results and included the precision, recovery and accuracy. It was also found that the excipients in the ...

Complexity in Acid–Base Titrations: Multimer Formation Between Phosphoric Acids and Imines

Solutions of Brønsted acids with bases in aprotic solvents are not only common model systems to study the fundamentals of proton transfer pathways but are also highly relevant to Brønsted acid catalysis. Despite their importance the light nature of the proton makes characterization of acid-base aggregates challenging. Here, we track such acid-base interactions over a broad range of relative com...